
Irrespective of their breed and age, all dogs are vulnerable to parasite infections. Therefore, it becomes important for dog parents to administer their canine babies with treatments that will help keep them protected all year round. Thankfully, there is a wide range of multi-parasite treatments available on the market including chewables, spot-on treatments and collars that are formulated to treat and control different species of internal and external parasites. In this blog, we will discuss two such popular dog parasitic treatments, Advantage Multi and Simparica Trio. We will also include a detailed comparison and help you choose the treatment that meets your dog’s requirements. Read on to find out more.
Advantage Multi and Simparica Trio – A Quick Glance
Advantage Multi
Advantage Multi is a monthly topical solution that effectively prevents heartworm disease caused by Dirofilaria immitis and treats circulating microfilariae in heartworm-positive dogs. The treatment kills adult fleas and treats flea infestations. It also treats and controls sarcoptic mange and intestinal worms like hookworms, roundworms and whipworms. The treatment is suitable for dogs and puppies from 7 weeks of age, weighing at least 3 lbs.
Simparica Trio
Simparica Trio is a pork liver flavored chewable that prevents heartworm disease caused by Dirofilaria immitis and treats and controls infections of roundworms and hookworms. It also kills adult fleas and treats and prevents flea infestations. The product also treats and controls tick infestations of lone star ticks, Gulf Coast ticks, American dog ticks, black-legged ticks, brown dog ticks and Asian longhorned ticks for one month. It is recommended for the prevention of Lyme disease infections in dogs and puppies from 8 weeks of age, weighing at least 2.8 lbs due to the direct result of killing black-legged ticks.
Advantage Multi and Simparica Trio – Similarities and Differences
Below are the similarities and differences between Advantage Multi and Simparica Trio.
Similarities
- Each of them kills adult fleas and useful in the treatment & prevention of flea infestations.
- Both the treatments prevent heartworm disease caused by Dirofilaria immitis.
- Both the products treat and control infections of roundworms and hookworms.
- Advantage Multi and Simparica Trio protects dogs against parasites for one month.
- The safe use of both Advantage Multi and Simparica Trio has not been evaluated in breeding, pregnant and lactating queens.
Differences
- While Advantage Multi is a topical treatment, Simparica Trio need to offered orally.
- While Advantage Multi is suitable for dogs and puppies from 7 weeks of age, Simparica Trio can be used in canines from 8 weeks.
- Advantage Multi is safe for dogs and puppies weighing at least 3 lbs. Whereas Simparica Trio can be used in canines weighing at least 2.8 lbs.
- Advantage Multi is composed of imidacloprid and moxidectin as its active ingredients. Simparica Trio, on the other hand, contains sarolaner, moxidectin and pyrantel.
- Advantage Multi doesn’t cover ticks. However, Simparica Trio protects against lone star ticks, Gulf Coast ticks, American dog ticks, black-legged ticks, brown dog ticks and Asian longhorned ticks.
- While Advantage Multi treats and controls whipworms and Sarcoptic Mange, Simparica Trio doesn’t cover these parasites.
- Simparica Trio of indicated for the prevention of Lyme disease infections due to the direct result of killing black-legged ticks. Advantage Multi offers no such coverage.
Detailed Comparison
The table below displays the comparison of product features of Advantage Multi and Simparica Trio:

Ending Note
Both Advantage Multi and Simparica Trio are vet-recommended treatments that protect dogs and puppies against a wide range of internal and external parasites. However, they differ when it comes to parasite coverage, composition, dosage as well as age and weight criterion. Therefore, it is important for you to carefully determine the requirements of your furry companion and choose a suitable treatment for it.
If you want to protect your pooch against fleas, heartworm diseaseand intestinal worms like hookworms and roundworms, either of the treatments can be used. However, if you are looking for protection against ticks (lone star ticks, Gulf Coast ticks, American dog ticks, black-legged ticks, brown dog ticks and Asian longhorned ticks), you should use Simparica Trio. For additional protection (along with fleas, heartworm disease and roundworms and hookworms) against whipworms and sarcoptic mange, you should go for Advantage Multi.
Advantage Multi and Simparica Trio are available on CanadaVetCare at discounted prices. Check out our online store today to enjoy attractive deals on your favorite parasitic treatments.

David joined CanadaVetCare in 2013 as a product analyst and veterinary assistant. Being a passionate pet lover and keen animal health researcher, David had always found ways and solutions to help pet parents to improve their pets’ health. He is always happy to answer pet health-related queries and recommending pet parents for the right pet product for their furry companions.